Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients

The Journal of Nuclear Medicine

article

Thomas W. Georgi¹  Dietrich Stoevesandt²  Lars Kurch¹  Jörg M. Bartelt²  Dirk Hasenclever³  Helmut Dittmann⁴  Jiri Ferda⁵  Peter Francis⁶  Christiane Franzius⁷  Christian Furth⁸  Daniel Gräfe⁹  Alexander Gussew²  Martin Hüllner^1,10  Leon J. Menezes^1,11  Mona Mustafa^1,12  Lars Stegger^1,13  Lale Umutlu^1,14  Klaus Zöphel^1,15  Pietro Zucchetta^1,16  Dieter Körholz^1,17  Osama Sabri¹  Christine Mauz-Körholz^1,17  Regine Kluge¹ 

[1] Department of Nuclear Medicine, University of Leipzig;Department of Radiology, University of Halle;Institute for Medical Informatics, Statistics, and Epidemiology, University of Leipzig;Department of Nuclear Medicine and Clinical Molecular Imaging, University Hospital Tuebingen;Department of Imaging, University Hospital Pilsen;Department of Nuclear Medicine, Royal Children’s Hospital;Center for Modern Diagnostics–MRI and PET/MRI and Center for Nuclear Medicine and PET/CT;Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt–Universität zu Berlin, and Department of Nuclear Medicine, Berlin Institute of Health;Paediatric Radiology, Department of Radiology, University of Leipzig;Department of Nuclear Medicine, University Hospital Zurich, University of Zurich;UCL Institute of Nuclear Medicine, University College London Hospitals;Department of Nuclear Medicine, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich;Department of Nuclear Medicine, University Hospital Muenster;Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen;Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden;Nuclear Medicine Unit, Department of Medicine, Padova University Hospital;Department of Pediatric Oncology, Justus Liebig University;Medical Faculty, Martin Luther University of Halle–Wittenberg

关键词: PET/MRI;    MRI sequences;    Hodgkin lymphoma;    whole-body imaging;   

DOI  :  10.2967/jnumed.122.264112

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

18F-FDG PET/MRI might be the diagnostic method of choice for Hodgkin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radiation exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anesthesia. Thus, a targeted selection of suitable whole-body MRI sequences is important to optimize the PET/MRI workflow. Methods: The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respective MRI sequence by the total number of lesions. Results: Relaxation time–weighted (T2w) transverse sequences with fat saturation (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation time–weighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). Conclusion: T2w transverse sequences with fs yielded the highest detection rates and are well suited for accurate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.

【 授权许可】

CC BY