Brain Trauma Imaging

The Journal of Nuclear Medicine

article

Gérard N. Bischof¹  Donna J. Cross³ 

[1] Department of Nuclear Medicine, University of Cologne;Institute for Neuroscience and Medicine II–Molecular Organization of the Brain, Research Center Juelich;Department of Radiology and Imaging Sciences, University of Utah

关键词: traumatic brain injury;    molecular imaging;    chronic traumatic encephalopathy;   

DOI  :  10.2967/jnumed.121.263293

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Imaging of mild traumatic brain injury (TBI) using conventional techniques such as CT or MRI often results in no specific imaging correlation that would explain cognitive and clinical symptoms. Molecular imaging of mild TBI suggests that secondary events after injury can be detected using PET. However, no single specific pattern emerges that can aid in diagnosing the injury or determining the prognosis of the long-term behavioral profiles, indicating the heterogeneous and diffuse nature of TBI. Chronic traumatic encephalopathy, a primary tauopathy, has been shown to be strongly associated with repetitive TBI. In vivo data on the available tau PET tracers, however, have produced mixed results and overall low retention profiles in athletes with a history of repetitive mild TBI. Here, we emphasize that the lack of a mechanistic understanding of chronic TBI has posed a challenge when interpreting the results of molecular imaging biomarkers. We advocate for better target identification, improved analysis techniques such as machine learning or artificial intelligence, and novel tracer development.

【 授权许可】

CC BY