The Role of Amyloid PET in Imaging Neurodegenerative Disorders: A Review

The Journal of Nuclear Medicine

article

Marianne Chapleau¹  Leonardo Iaccarino¹  David Soleimani-Meigooni¹  Gil D. Rabinovici¹ 

[1] Memory and Aging Center, Department of Neurology, University of California;Weill Institute for Neurosciences, University of California;Department of Radiology and Biomedical Imaging, University of California

关键词: neurology;    PET;    PET/MRI;    Alzheimer disease;    amyloid PET;    neurodegenerative diseases;   

DOI  :  10.2967/jnumed.121.263195

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Imaging of amyloid deposition using PET has been available in research studies for 2 decades and has been approved for clinical use by the U.S. Food and Drug Administration, the European Medicines Agency, and other regulatory agencies around the world. Amyloid PET is a crucial tool for the diagnosis of Alzheimer disease, as it allows the noninvasive detection of amyloid plaques, a core neuropathologic feature that defines the disease. The clinical use of amyloid PET is expected to increase with recent accelerated approval in the United States of aducanumab, an antiamyloid monoclonal antibody, for the treatment of mild cognitive impairment and mild dementia due to Alzheimer disease. However, amyloid pathology can also be found in cognitively unimpaired older adults and in patients with other neurodegenerative disorders. The aim of this review is to provide an up-to-date overview of the application of amyloid PET in neurodegenerative diseases. We provide an in-depth analysis of the clinical, pathologic, and imaging correlates; a comparison with other available biomarkers; and a review of the application of amyloid PET in clinical trials and clinical utility studies.

【 授权许可】

CC BY