Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging

The Journal of Nuclear Medicine

article

John C. Stendahl¹  Jennifer M. Kwan¹  Darko Pucar²  Mehran M. Sadeghi¹ 

[1] Section of Cardiovascular Medicine, Yale University School of Medicine;Department of Radiology and Biomedical Imaging, Yale University School of Medicine;Veterans Affairs Connecticut Healthcare System

关键词: cardiology (basic/technical);    cardiology (clinical);    molecular imaging;    inflammation;    myocardial perfusion imaging;   

DOI  :  10.2967/jnumed.121.263506

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The development of new radiotracers for PET and SPECT is central to addressing unmet diagnostic needs related to systemwide trends toward molecular characterization and personalized therapies in cardiovascular medicine. In the following 2-part review, we discuss select emerging radiotracers that may help address important unmet diagnostic needs in central areas of cardiovascular medicine, such as heart failure, arrhythmias, valvular disease, atherosclerosis, and thrombosis. Part 1 examines key technical considerations pertaining to cardiovascular radiotracer development and reviews emerging radiotracers for perfusion and neuronal imaging. Highlights of this work include discussions on the development of 18F-flurpiridaz, an emerging PET perfusion tracer, and the development of 18F-based radiotracers for cardiovascular neuronal imaging, such as 18F-flubrobenguane. Part 2 of this review covers emerging radiotracers for the imaging of inflammation, fibrosis, thrombosis, calcification, and cardiac amyloidosis.

【 授权许可】

CC BY