Short-term adverse effects of COVID-19 vaccines after the first, second, and booster doses: a cross-sectional survey from Punjab, Pakistan, and the implications

Sociedade Brasileira de Medicina Tropical. Revista

article

Mustafa, Zia Ul¹  Maqbool, Fareeha²  Wahid, Mahnoor³  Salman, Muhammad⁴  Haroon, Shahzaib⁵  Khan, Yusra Habib⁶  Mallhi, Tauqeer Hussain⁶  Godman, Brian⁷ 

[1] Universiti Sains Malaysia;Faisalabad Medical University;Nishtar Medical University;Lahore College for Women University;District Headquarters Hospital;Jouf University;Sefako Makgatho Health Sciences University

关键词: Adverse effects;    COVID-19;    Pharmacovigilance;    Vaccines;    Pakistan;   

DOI  :  10.1590/0037-8682-0044-2023

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Background:Safety and efficacy concerns regarding coronavirus disease 2019 (COVID-19) vaccines are common among the public and have a negative impact on their uptake. We aimed to report the adverse effects currently associated with the vaccine in Pakistan to build confidence among the population for its adoption.Methods:A cross-sectional study was conducted in five districts of the Punjab province of Pakistan between January and March 2022. The participants were recruited using convenience sampling. All data were analyzed using SPSS 22. Results:We recruited 1622 people with the majority aged between 25-45 years. Of these, 51% were female, including 27 pregnant women and 42 lactating mothers. Most participants had received the Sinopharm (62.6%) or Sinovac (17.8%) vaccines. The incidences of at least one side effect after the first (N = 1622), second (N = 1484), and booster doses (N = 219) of the COVID-19 vaccine were 16.5%, 20.1%, and 32%, respectively. Inflammation/erythema at the injection site, pain at the injection site, fever, and bone/muscle pain were common side effects of vaccination. No significant differences were observed in the adverse effect scores between all demographic variables except for pregnancy (P = 0.012) after the initial dose. No significant association was observed between any variable and the side effect scores of the second and booster doses of the vaccine.Conclusions: Our study showed a 16-32% prevalence of self-reported side effects after the first, second, and booster COVID-19 vaccinations. Most adverse effects were mild and transient, indicating the safety of different COVID-19 vaccines.

【 授权许可】

CC BY