DETERMINATION OF IBUPROFEN AND 1-HYDROXYIBUPROFEN IN AQUEOUS SAMPLES USING CORK AS A NATURAL PHASE IN ROTATING-DISK SORPTIVE EXTRACTION

Journal of The Chilean Chemical Society

article

Valentina Rojas-Candia¹  Daniel Arismendi¹  Pablo Richter¹ 

[1] Department of Inorganic and Analytical Chemistry, University of Chile

关键词: Cork;    Ibuprofen;    1-Hydroxyibuprofen;    Natural Sorptive Phase;    RDSE;   

DOI  :  10.4067/S0717-97072022000405722

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Ibuprofen is one of the most widely used nonsteroidal anti-inflammatory drugs due to its analgesic, anti-inflammatory and antipyretic properties, as well as its low cost and easy accessibility. A fraction of the compound and its metabolites are excreted in the urine, being eliminated in the wastewater reaching river waters in the range of ng L-1 to μg L-1. In this context, highly sensitive and selective analytical methods are required to quantify them, including these methods a pre-concentration step. In this work, the use of a microextraction technology based on rotating-disk sorptive extraction, involving a sorptive phase of laminar cork, was implemented for the extraction of ibuprofen and 1-hydroxyibuprofen from aqueous samples and their subsequent determination by gas chromatography coupled to mass spectrometry.The optimal conditions for determination of the analytes were: 20 mL of sample volume, pH 2, 20 % w/v NaCl (to increase the ionic strength), 90 min of extraction time and 2000 rpm of rotation velocity of the disk. Recoveries of 118 and 39 % and relative standard deviations of 6 and 13 % for ibuprofen and 1-hydroxyibuprofen were obtained, respectively. The presence of both compounds in river waters (Mapocho river, Santiago of Chile) at a concentration of 2.56 to 4.08 μg L-1 were found. The use of laminar cork as a natural sorbent phase immobilized in the rotating-disk allowed to extract the analytes from water samples through its lipophilic-hydrophilic balance that favors the interaction with the compounds under study.

【 授权许可】

Unknown