SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE

Journal of The Chilean Chemical Society

article

Rodrigo Ramirez-Tagle¹  Guillermo Salgado-Moran²  David Mendez-Luna³  José Correa-Basurto³  Wilson Cardona Villada⁴  Lorena Gerli Candia⁵  Luis H. Mendoza-Huizar⁶ 

[1] Universidad Pedro de Valdivia;Universidad de Concepcion;Laboratorio de Modelado Molecular y Diseño de Fármacos, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional;Facultad de Ciencias Exactas, Departamento de Quimica, Universidad Andres Bello;Departamento de Química Ambiental, Facultad de Ciencias, Universidad Católica de la Santísima Concepción;Autonomous University of Hidalgo State. Academic Area of Chemistry. Carreter

关键词: Amlodipine;    Chitosan;    Nanocomposite;    Drug-release properties;    Docking studies;   

DOI  :  10.4067/S0717-97072021000105063

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

【 授权许可】

Unknown