A Study Of Serum Aminotransferase Levels In Subjects With Chronic Kidney Disease Attending A Tertiary Care Hospital In Perambalur.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Nageshwari A¹  B Sudha Presanna¹  K Geetha.¹ 

[1]Department of Biochemistry, Government Stanley Medical College

关键词: Alanine aminotransferase;    alkaline phosphatase;    aspartate aminotransferase;    chronic kidney disease;    end-stage renal disease;    liver enzymes.;   

DOI  :  10.33887/rjpbcs/2023.14.3.35

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Hepatic diseases are common among chronic kidney disease patients and liver function testsparticularly serum liver enzymes play an important role in diagnosing and monitoring these patients.Serum aminotransferase levels commonly fall near the lower end of the range of the normal values inpatients of chronic kidney disease (CKD). High-levels of serum alkaline phosphatase (ALP) can occur inthese patients due to renal osteodystrophy. Thus, the recognition of liver damage in these patients ischallenging.To estimate and compare the serum aminotransferase levels between subjects with CKD andapparently healthy controls. This prospective cross-sectional observational study was conducted for aduration of six months from January 2018 to June 2018 among subjects attending the out-patientdepartment in Department of Nephrology, Dhanalakshmi Srinivasan Medical College Hospital located inPerambalur. The study involved two groups of subjects named Group A and B. Subjects in Group A were 30patients with chronic Kidney Disease (CKD) but without end stage renal disease (ESRD) (eGFR >152 ml/min/ 1.73m ) and Group B consisted of 30 apparently healthy subjects without any known renaldisorders .All tests were performed using automated routine chemistry analyser with commercial kits(Roche, Germany) according to manufacturer’s protocol. : In the current study, Group A subjects with CKD(stage 1 to 4) had a mean age (± S.D) of 49.4 (± 12.4) years in comparison to 48.2 (± 13.4) years in GroupB subjects and this difference was not statistically significant (p = 0.723). There was no statisticallysignificant difference between the two groups in terms of gender distribution. Levels of serumaminotransferases were low in CKD with and without ESRD and the levels become lower as the severity ofCKD increases. Thus, the study established the need for separate reference ranges of serumaminotransferase in different stages of CKD.

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