Hepatoprotective activity of mangrove snail (Telescopium sp.) extract in sprague dawley rats induced by paracetamol

2nd International Conference on Integrated Coastal Management and Marine Biotechnology,

Purwaningsih, S.^1 ; Handharyani, E.^2 ; Ananda, W.A.R.^1

Aquatic Product Technology, Faculty of Fisheries and Marine Sciences, IPB, Sri Lanka^1

Clinical Pathology, Faculty of Veterinary Medicine, IPB, Sri Lanka^2

关键词: Alanine aminotransferase;    Anti-oxidant activities;    Aspartate aminotransferase;    Bioactive compounds;    Completely randomized designs;    Hepatoprotective activities;    Histopathological analysis;    Sprague-Dawley rats;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/241/1/012022/pdf
DOI  :  10.1088/1755-1315/241/1/012022

来源: IOP

【 摘 要 】

The preliminary study showed that mangrove snails contain bioactive compounds and possess antioxidant activity, whereas these snails are only considered as pond pests. This study aimed to determine the activity of mangrove snails (Telescopium sp.) as hepatoprotective in Sprague Dawley rats induced by paracetamol. This study used a completely randomized design (CRD) with Duncan's follow-up test, where mice were divided into 6 treatment groups (with n = 3). The observations included the levels of enzyme serum Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and, malondialdehyde (MDA), and histopathological tissue. The results of histopathological analysis showed that dose of 75 mg/kg body weight were protective and repair on rat liver tissue.