Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes

BMC Pediatrics

Gabriel Q Shaibi¹  Martha Nunez¹  Omar D Hudson² 

[1] College of Nursing and Health Innovation, Arizona State University, 500 N. 3rd St., Phoenix, AZ, 85004, USA;Division of Pediatric Endocrinology and Diabetes, Phoenix Children’s Hospital, Phoenix, AZ, USA

关键词: Aspartate aminotransferase;    Alanine aminotransferase;    Fatty liver;    Type 2 diabetes mellitus;   

Others  :  1170617
DOI  :  10.1186/1471-2431-12-174

 received in 2012-06-28, accepted in 2012-10-25,  发布年份 2012

【 摘 要 】

Background

To examine the influence of ethnicity on liver transaminases among adolescents with type 2 diabetes mellitus (T2DM).

Methods

A retrospective medical chart review of 57 (30 males and 27 females) newly diagnosed patients with T2DM. Ethnicity was determined by self-report and height, weight, body mass index (BMI) and glycosylated hemoglobin (HbA1c) were obtained using standard clinical procedures. Fasting levels of alanine aminotransaminase (ALT) and aspartate aminotransferase (AST) were collected prior to the initiation of any therapy.

Results

Age, gender, height, weight, BMI, and HbA1c did not differ between ethnic groups. Compared to African-Americans, Hispanics had significantly higher ALT (23.9 ± 3.4 vs. 107.8 ± 20.3, p=0.002) and AST (17.7 ± 2.5 vs. 71.1 ± 15.7, p<0.001) and were significantly more likely to have ALT values above the upper limit of normal (20% vs. 71%, p=0.005) and twice the upper limit of normal (0% vs. 39%, p=0.05) as well as AST values above the upper limit of normal (0% vs. 53%, p=0.002). No differences in ALT or AST were found between Hispanics and non-Hispanic whites or between African-Americans and non-Hispanic whites.

Conclusions

These preliminary findings suggest that Hispanic children with T2DM may be at higher risk for developing non-alcoholic fatty liver disease and indicate that a comprehensive hepatic evaluation is warranted in this population. Future studies that incorporate more precise and proximal measures of liver health are warranted in this population.

【 授权许可】

   
2012 Hudson et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 4.

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