A Hospital Based Case Control study on Serum Lipid Profile in Patients with Active Rheumatoid Arthritis attending a tertiary care center in Chennai, Tamil Nadu, India.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

KarthigaMurugan¹  Velmurugan Anbuananthan²  S Michael Rajam Geetha³  Vijayalakshmi Masilamani.¹ 

[1] Department of Biochemistry, Govt. Theni Medical College;Department of Community Medicine, Govt. Theni Medical College;Department of Biochemistry, Govt. Thoothukudi Medical College

关键词: Rheumatoid Arthritis;    Lipid profile;    HDL;    LDL;    Triglycerides;    Cholesterol;   

DOI  :  10.33887/rjpbcs/2022.13.4.19

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Epidemiological studies have observed increased premature cardiovascular morbidity andmortality in Rheumatoid Arthritis patients. Lipid profile has not been evaluated as a primary risk factorfor Cardiovascular morbidity and mortality in these patients. The present study was carried out to assessthe Lipid Profile in RA patients. A Case control study was carried out on 55 RA patients with activedisease and 27 age, sex matched healthy controls. Rheumatoid arthritis patients were chosen based onACR criteria 2010. Serum Total Cholesterol, Triglyceride, HDL and LDL were measured. Statisticalanalysis was done using Epi info version 7.2.5.0. Unpaired student’s t-test at 5 % significance was done tocompare the parameters between cases and controls.There was a significant difference between casesand controls with regards to mean Total Cholesterol (170±36.2mg/dL in cases vs 149±39.2 mg/dL incontrols, p=0.017), mean Triglyceride (123±41.1mg/dL Vs 98±34.1 mg/dL, p=0.006), mean HDL(47±11.4mg/dL Vs 43±9.6mg/dL, p= 0.049) and mean LDL (98±25.1mg/dLVs 87±27.8mg/dL, p =0.075).The Lipid Profile and the derived atherogenic indices from this lipid profile are elevated in Casescompared to controls, which indicates a higher Cardiovascular risk in RA. Hence early diagnosis, healtheducation, awareness and management of cardiovascular diseases is of paramount importance in subjectswith RA.

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