Improvement in Solubility by Solid Dispersion Techniques via Freeze Drying method of Antiepileptic Drug.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Ashish P. Gorle¹  Shubham S. Bagal¹  Vijay S. Khalane.¹ 

[1] R.C. Patel Institute of Pharmaceutical and Research

关键词: Carbamazepine;    Solid dispersion;    Neusilin US2;    Pluronic F68;    Freeze drying;    physical characterization.;   

DOI  :  10.33887/rjpbcs/2022.13.2.15

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Present studies demonstrated that solid dispersion prepared by freeze drying method improvesthe carbamazepine solubility and tablets prepared from such solid dispersion achieves faster dissolution.Solid dispersions were prepared by Neusilin US2 and Pluronic F68 carrier. The developed soliddispersion's were then subjected to characterization includes micromeritics, rheological properties andDrug content. The friability, hardness, in-vitro dissolution and disintegration time of carbamazepinetablets were also examined prepared by the direct compression method. The experimental design of theCarbamazepine solid dispersions shows the effects of the Neusilin US2 and Pluronic F-68 on the drugcontent and the dissolution profile. It shows that when the concentration of the both the excipients is atlower and higher side according to the design given by design expert software, the drug content anddissolution profile getting poor. But when concentration of the both excipients was at optimum level(middle level) then prepared solid dispersion gives good dissolution profile and higher drug content.Optimized formulation F-4 shows enhanced solubility of drug, 92% of the drug content and dissolution ofthe drug from solid dispersion in 30 minutes goes to 98%. Conclusively, solid dispersion formulation withNeusilin US2 as a high specific surface area adsorption carrier and Pluronic F68 as an amphiphilicpolymer was successfully used to improve solubility of Carbamazepine. From the present study, it can beconcluded that the solid dispersion prepared by freeze drying technique shows the good increase insolubility, better dissolution profiles, when compared with the pure drug.

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