Possible Protective Effect Of Curcumin Encapsulated Nanoparticles Against Colon Carcinogenesis In Male Mice.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Farida E Elbassiouni¹  Wafaa M El-Kholy¹  El-Sayed M Elhabibi.¹ 

[1] Zoology Department, Faculty of Science, Mansoura University

关键词: Nanocurcumin;    colon cancer;    ACF;    P53;    caspase 3;    Bcl-2;   

DOI  :  10.33887/rjpbcs/2021.12.2.21

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Colon cancer is the third most common cancer, there are previous studies demonstrated that nanocurcumin issafely used against different cancers and more effective than normal curcumin(CUR). Our study aim is studying theprotection effect of CUR-encapsulated poly (lactic-coglycolic acid) (PLGA) nanoparticles (CUR@PLGA) against coloncarcinogenesis induced by dimethyl hydrazine (DMH) in mice. Also performed to evaluate the potential effect ofnanoparticles for enhancing CUR bioavailability. The mice were randomly divided into 6 groups. The control group. TheDMH group. The CUR group, CUR@PLGA group, DMH and CUR group and DMH and CUR@PLGA group. The animals weresacrificed at the end of 6 weeks. The results showed using CUR@PLGA made a significant improvement in the level ofoxidative stress markers and anti-oxidants. CUR@PLGA showed significant increase in tumor protein P53 level, caspase3 and Bcl-2 associated X protein (BAX) also significant decrease on B cell lymphoma 2 (Bcl-2) level. The Aberrant creptfoci (ACF) that represent the first stage on colon carcinogenesis is significantly reduced in number on CUR@PLGA group.Our study reveals that CUR@PLGA have a great effect on antioxidants, apoptotic proteins and ACF. So, it provides aninsight towards the use of biological sources as promising anticancer agents.

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