Therapeutic role of curcumin and its novel formulations in gynecological cancers

Journal of Ovarian Research

Moghaddaseh Jahanshahi¹  Maryam Darvish²  Reza Mottaghi³  Mahboobeh Rabbani Fard⁴  Javad Tabatabaeian⁴  Mohammad Hossein Pourhanifeh⁵  Amirhossein Sahebkar⁶  Hamed Mirzaei⁷  Mohammad Javad Azadchehr⁸ 

[1] Clinical Research Development Center (CRDC), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran;Department of Medical Biotechnology, Faculty of Medicine, Arak University of Medical Science, Arak, Iran;Department of Oral and Maxillofacial Surgery, Kashan University of Medical Sciences, Kashan, Iran;Faculty of Member, Ardestan Branch, Islamic Azad University, Ardestan, Iran;Halal Research Center of IRI, FDA, Tehran, Iran;Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran;Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran;

关键词: Curcumin;    Nanocurcumin;    Endometrial cancer;    Ovarian cancer;    Cervical cancer;    Curcumin derivatives;    Natural compound;   

DOI  :  10.1186/s13048-020-00731-7

来源: Springer

【 摘 要 】

Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to improve efficacy of the treatment process and patients’ quality of life, searching for novel adjuvant treatments is highly warranted. Curcumin, a promising natural compound, is endowed with numerous therapeutic potentials including significant anticancer effects. Recently, various investigations have demonstrated the anticancer effects of curcumin and its novel analogues on gynecological cancers. Moreover, novel formulations of curcumin have resulted in further propitious effects. This review discusses these studies and highlights the possible underlying mechanisms of the observed effects.

【 授权许可】

CC BY