Mitochondrial DNA as A Marker of In-Vitro Fertilization Outcome in Polycystic Ovarian Syndrome Patients.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Ghadir A. Sayed¹  Hussein A. Al-Sawaf¹  Ahmed Hussein Ali El-Sawaf²  Iman Hassan Ibrahim.³ 

[1] Department of Biochemistry, Faculty of Pharmacy Egyptian Russian University;Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University and Gana center for IVF;Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University

关键词: Mitochondrial DNA;    oocyte quality;    embryo viability;    pregnancy outcomes.;   

DOI  :  10.33887/rjpbcs/2020.11.5.17

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Polycystic Ovarian Syndrome (PCOS) is the most common reproductive disorder that affects 6-10% ofall women in reproductive age. This syndrome is characterized by clinical or biochemical hyperandrogenism,oligo-anovulation, and polycystic ovaries, with concurrent hormonal and metabolic alterations that alter thefollicle maturation and reduce oocyte quality. In Vitro Fertilization (IVF) has been used as an intervention toimprove pregnancy rates. IVF pregnancy outcomes after embryo transfer could remain low due to poor oocytequality. Embryo selection is mainly based on morphological criteria. However, good morphology of the embryodoes not necessarily indicate good functional status, some of these embryos might be genetically abnormal.The change in mitochondrial DNA (mtDNA) copy number is related to the occurrence, severity of PCOS, andoocyte maturation. Mature oocytes usually contain at least 100,000 mtDNA copies, which are necessary fornormal development. The number of mtDNA remains stable, and the maintenance of mtDNA copy numbers atan appropriate level is crucial for maintaining mitochondrial function and cell growth. This review summarizesthe recent findings for mtDNA as a marker for IVF embryo viability and selection for implantation andpredicting pregnancy outcomes.

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