Intensity Of Protein Oxidative Modification’s Processes In The Dynamics Of A Full Thickness Wound Healing In Pharmacotherapy By Gel With Sapropel Extract.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Strus Oksana¹  Polovko Natalia.² 

[1] Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University;Department of Drug Technology, National University of Pharmacy

关键词: peloids;    sapropel;    saprogel;    protein oxidative modification;    antioxidant activity.;   

DOI  :  10.33887/rjpbcs/2020.11.3.8

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Sapropel is a valuable raw material resource of Ukraine, the extraction of which can satisfy needs indifferent national economies, including health and ecology protection. The advantage of using peloid-basedpreparations are possibility to use them in the acute phase of the inflammatory process and absence ofbalneological reactions. The processes of free radical oxidation is a component of metabolic cell activity thatoccur constantly in living organisms. The cell membranes are composed of proteins that undergo oxidativemodification, so the aim of our research was to study the intensity of these processes in the dynamics of a full- thickness excision wound healing in rats when using the gel with sapropel extract under the provisional name"Saprogel". The study of the process intensity of protein oxidative modification was performed in the dynamicsof a thickness excised plane wound healing in pharmacotherapy with the with sapropel gel, carbopol-based geland the reference sample "Pantestin-Darnitsa" (Ukraine), comparing them with indicators of intact animalsand control pathology groups. In the serum of rats determined the content of theprotein oxidativemodification products and the level of sulfhydryl groups. It is revealed that in a full-thickness excision woundunder the conditions of using the drug "Saprogel" in blood serum a decrease in the level of protein moleculeoxidation and the restoration of the sulfhydryl group content, a decrease in the activation of free radicalprocesses and an increase of antioxidant protection are detected, which provide the stabilization of cellmembranes, can be due to the pronounced antioxidant properties of sapropel extract.

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