Clinical Significance Of Neutropil To Lymphocyte Ratio In The Assessment The Severity Of Chronic Obstructive Pulmonary Disease.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Zeinab H. El Sayed¹  Zeinab Adawy.² 

[1] Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University;Chest Diseases Department, Faculty of Medicine for Girls, Al-Azhar University

关键词: Chronic Obstructive Pulmonary Disease;    Neutrophil to Lymphocyte ratio;    Neutrophil count;    Lymphocyte count.;   

DOI  :  10.33887/rjpbcs/2019.10.3.63

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Chronic obstructive pulmonary disease (COPD) is a debilitating condition characterized by permanentairflow limitation with pulmonary and systemic inflammation. Several studies reported that the neutrophil tolymphocyte ratio (NLR) in the peripheral blood was considered as a prognostic marker in several inflammatorydiseases. Therefore, we aimed to evaluate the clinical significance of the NLR in the assessment of the severityCOPD according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline. 120 COPDpatients conducted in this study were divided into four groups according to the GOLD severity of airflowlimitation into mild (G-I), moderate (G-II), severe (G-III), and very severe (G-IV) groups. Complete blood counts(CBC), C Reactive protein (CRP) were measured and the NLR was calculated according to the neutrophil andlymphocyte counts from CBC. Spirometry was done at least three times for all patients. The severity of thesymptom was determined by the Modified Medical Research Council breathlessness score. We used the COPDassessment test score to assess a patient’s life. We found that the neutrophil count was gradually elevatedfrom G-I to G-IV, in spite of the lymphocyte count which gradually decreased from G-I to G-IV. There was nosignificant difference in the total leucocytic count when compared it between the different groups. Themaximum elevation of NLR was found in G-IV but the minimum was found in G-I. NLR was found to besignificantly elevated in G-IV than G-III and significantly elevated in G-III than G-II, also, significantly elevated inG-II than G-I. NLR was inversely correlated with forced vital capacity (FVC) (r= -0.316, p= 0.000), forcedexpiratory volume in the 1 second (FEV1) (r= -0.390, p= 0.000) and FEV1/FVC(r= 0.234, p= 0.010). NLR waseasily and cheap inflammatory marker which can be used as a follow-up inflammatory marker for COPDpatient to assess the progression of COPD.

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