Synthesis And Biological Activity Of 8-Aminosubstituted 7-(2-Hydroxy-3-M-Ethylphenoxypropyl-1)-3-Methylxanthine.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Dmytro Ivanchenko¹  Mykola Romanenko¹  Oleksandr Goloborodko¹  Oleksandr Kamyshnyi¹  Natalia Polishchuk.¹ 

[1] Zaporizhzhia state medical university

关键词: xanthine;    organic synthesis;    H NMR-spectroscopy;    antibacterial;    antifungal agents.;   

DOI  :  10.33887/rjpbcs/2019.10.3.50

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The reaction of 8-bromo-3-methylxanthine with m-ethylphenoxymethyloxirane in Propanol-1 mediumin the presence of N, N-dimethylbenzylamine leads to formation of the initial 8-bromo-7-(2-hydroxy-3-m- ethylphenoxypropyl-1)-3-methylxanthine. Interactions of the 8-bromo-7-(2-hydroxy-3-m-ethylphenoxypropyl- 1)-3-methylxanthine with primary alkyl, oxyalkyl, aminoalkylamines and some dialkyl amines were studied.1 Structure of synthesized compounds was definitely proved by H NMR-spectroscopy. Conducting primaryscreening research of antimicrobial activity of 8-aminosubstituted 7-(2-hydroxy-3-m-ethylphenoxypropyl-1)-3- methylxanthine, which revealed moderate and weak activity in concentrations 50-200 mcg/ml.

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