Preparation and Stability Study of Glibenclamide Encapsulated Nanostructured Lipid Carrier

RGUHS Journal of Pharmaceutical Sciences

article

Ashwini M¹  Preethi Sudheer¹  Bharani S Sogali² 

[1] Department of Pharmaceutics, Krupanidhi College of Pharmacy;Healthcare Hospital

关键词: Nanostructured lipid carriers;    Glibenclamide;    Storage condition;    Lipid ratio optimization;   

DOI  :  10.26463/rjps.12_1_5

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Background: Nanostructured lipid carriers (NLCs) are lipid form of nanoparticles with an unstructured solid and liquid lipid core that allows for the intercalation of hydrophilic/lipophilic drugs, guarding them from deterioration and increasing their stability. NLC is a current evolution of colloidal vehicles composed of lipids, water, and surfactants that allow for the elimination of many of the constraints and disadvantages of older lipoidal systems.Aim of the study: The most important characteristics that distinguish NLC from first-generation solid lipid nanoparticles are greater drug loading and higher stability (SLN). In the current study, glibenclamide NLCs were synthesised using the hot homogenization technique with ultrasonication and then subjected to stability studies. The lipid ratio optimization was done using a custom design with the help of JMP pro-13.Methodology : Stability studies of prepared NLCs were assessed by keeping the formulation in sealed glass containers at 25±2ºC / 60±5% RH and 40±2ºC / 75±5% RH for six months, and then evaluated for various parameters to inscribe changes.Results: The results showed no significant changes in the NLCs during the six months of its storage period at the specified conditions.Conclusion: Hence, it may be inferred that prepared NLCs were stable and room temperature could be the suitable condition for storage of the prepared glibenclamide NLCs Background: Nanostructured lipid carriers (NLCs) are lipid form of nanoparticles with an unstructured solid and liquid lipid core that allows for the intercalation of hydrophilic/lipophilic drugs, guarding them from deterioration and increasing their stability. NLC is a current evolution of colloidal vehicles composed of lipids, water, and surfactants that allow for the elimination of many of the constraints and disadvantages of older lipoidal systems.Aim of the study: The most important characteristics that distinguish NLC from first-generation solid lipid nanoparticles are greater drug loading and higher stability (SLN). In the current study, glibenclamide NLCs were synthesised using the hot homogenization technique with ultrasonication and then subjected to stability studies. The lipid ratio optimization was done using a custom design with the help of JMP pro-13.Methodology : Stability studies of prepared NLCs were assessed by keeping the formulation in sealed glass containers at 25±2ºC / 60±5% RH and 40±2ºC / 75±5% RH for six months, and then evaluated for various parameters to inscribe changes.Results: The results showed no significant changes in the NLCs during the six months of its storage period at the specified conditions.Conclusion: Hence, it may be inferred that prepared NLCs were stable and room temperature could be the suitable condition for storage of the prepared glibenclamide NLCs.

【 授权许可】

CC BY