Preparation of Additol Antiseptic and Disinfectant Solution

RGUHS Journal of Pharmaceutical Sciences

article

Paul Richards M¹  Nashra Anjum¹  Sharlet¹  Spoorthy¹  Paranjothy Kanni¹  Guddu shah¹  B A Viswanath¹ 

[1]Aditya Bangalore Institute of Pharmacy Education and Research

关键词: Additol;    Castor oil;    Sodium hydroxide;    Terpineol oil;    Basil oil;    Proplyene glycol;   

DOI  :  10.26463/rjps.11_4_3

学科分类：药学、药理学、毒理学（综合）

来源: Rajiv Gandhi University of Health Sciences

【 摘 要 】

Background: Antiseptics and disinfectants are mandatory equipment to maintain hygienic environment in hospitals and other health care settings which includes sanitizers, preservatives and sporisites. Additol is a preparation in which the main chemical constituents are Terpineol, castor oil, basil oil, propylene glycol and small quantity of liquid caramel, made to sufficient quantity of one litre.Objective: Castor oil and Sodium hydroxide gives the soap solution and followed by different analytical tests like saponification tests and all the values are validated and these are considered under the jurisdiction of FDA testing guidelines done for the activity and application of disinfectants. Currently, during this pandemic it is used in medical settings to stop the spread of viruses.Methodology: Castor oil and Sodium hydroxide (NaOH) were used in the preparation of soap solution. Terpineol oil, basil oil, propylene glycol, and liquid caramel were further used in the preparation.Results: The results were in good agreement, and were performed under the testing guidelines. Tests were carried out to determine the antimicrobial activity, and the obtained results were enclosed by standard limits. By following the standard procedure, under the FDA testing guidelines, prepared product Additol was compared with marketed product, Dettol using Riedel-Walker Co-efficient test and the procured values were within the range.Conclusion: The proposed Additol 1000 ml was evaluated for the disinfectant activity following standard procedure. The proposed disinfectant exhibited good disinfectant activity against the test microorganisms. Background: Antiseptics and disinfectants are mandatory equipment to maintain hygienic environment in hospitals and other health care settings which includes sanitizers, preservatives and sporisites. Additol is a preparation in which the main chemical constituents are Terpineol, castor oil, basil oil, propylene glycol and small quantity of liquid caramel, made to sufficient quantity of one litre.Objective: Castor oil and Sodium hydroxide gives the soap solution and followed by different analytical tests like saponification tests and all the values are validated and these are considered under the jurisdiction of FDA testing guidelines done for the activity and application of disinfectants. Currently, during this pandemic it is used in medical settings to stop the spread of viruses.Methodology: Castor oil and Sodium hydroxide (NaOH) were used in the preparation of soap solution. Terpineol oil, basil oil, propylene glycol, and liquid caramel were further used in the preparation.Results: The results were in good agreement, and were performed under the testing guidelines. Tests were carried out to determine the antimicrobial activity, and the obtained results were enclosed by standard limits. By following the standard procedure, under the FDA testing guidelines, prepared product Additol was compared with marketed product, Dettol using Riedel-Walker Co-efficient test and the procured values were within the range.Conclusion: The proposed Additol 1000 ml was evaluated for the disinfectant activity following standard procedure. The proposed disinfectant exhibited good disinfectant activity against the test microorganisms.

【 授权许可】

CC BY