期刊论文详细信息
Journal of Thoracic Disease | |
Real-world experience of arbidol for Omicron variant of SARS-CoV-2 | |
article | |
Jingya Zhao1  Yong Li1  Rong Chen1  Yanping Xu1  Qingyuan Yang1  Haiqing Zhang1  Zhengxin Yin4  Weiting Gu5  Jinsong Hu6  Li Chen7  Jian Li8  Guang Ning9  Qijian Cheng1  Min Zhou1  Jieming Qu1  | |
[1]Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
[2]Institute of Respiratory Disease, Shanghai Jiaotong University School of Medicine | |
[3]Shanghai Key Laboratory of Emergency Prevention | |
[4]Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
[5]Department of Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
[6]Department of Traumatology of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
[7]Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine | |
[8]Clinical Research Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
[9]Shanghai National Research Centre for Endocrine and Metabolic Disease, State Key Laboratory of Medicine Genomics, Shanghai Institute for Endocrine and Metabolic Disease, Ruijin Hospital, Shanghai Jiaotong University School of Medicine | |
关键词: Arbidol; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Omicron; efficacy; safety; | |
DOI : 10.21037/jtd-22-980 | |
学科分类:呼吸医学 | |
来源: Pioneer Bioscience Publishing Company | |
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【 摘 要 】
Background: At a crucial time with the rapid spread of Omicron severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus variant globally, we conducted a study to evaluate the efficacy and safety of arbidol tablets in the treatment of this variant. Methods: From Mar 26 to April 26, 2022, we conducted a prospective, open-labeled, controlled, and investigator-initiated trial involving adult patients with confirmed Omicron variant infection. Patients with asymptomatic or mild clinical status were stratified 1:2 to receive either standard-of-care (SOC) or SOC plus arbidol tablets (oral administration of 200 mg per time, three times a day for 5 days). The primary endpoint was the negative conversion rate within the first week. Results: A total of 367 patients were enrolled in the study; 246 received arbidol tablet treatment, and 121 were in the control group. The negative conversion rate of SARS-CoV-2 within the first week in patients receiving arbidol tablets was significantly higher than that of the SOC group [47.2% (116/246) vs. 35.5% (43/121); odds ratio (OR), 1.619; 95% confidence interval (CI): 1.034–2.535; P=0.035]. Compared to those in the SOC group, patients receiving arbidol tablets had a shorter negative conversion time [median 8.3 vs. 10.0 days; hazard ratio (HR), 0.645; 95% CI: 0.516–0.808; P<0.001], and a shorter duration of hospitalization (median 11.4 vs. 13.7 days; HR, 1.214; 95% CI: 0.966–1.526; P<0.001). Moreover, the addition of arbidol tablets led to better recovery of declined blood lymphocytes, CD3+, CD4+, and CD8+ cell counts. The most common adverse event (AE) was transaminase elevation in patients treated with arbidol tablets (3/246, 1.2%). No one withdrew from the study due to AEs or disease progression. Conclusions: As a whole, arbidol may represent an effective and safe treatment in asymptomatic-mild patients suffering from Omicron variant during the pandemic of coronavirus disease 2019 (COVID-19).【 授权许可】
Unknown
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