A multicenter survey on the current status of chronic cough and its impact on quality of life in Guangdong, China

Journal of Thoracic Disease

article

Kefang Lai¹  Lianrong Huang¹  Haijin Zhao²  Feng Wu³  Guocui Zhen⁴  Haiyan Deng⁵  Wei Luo¹  Wen Peng¹  Mei Jiang¹  Fang Yi¹  Jianxin Sun⁶  Pusheng Xu⁷  Yuqi Zhou⁸  Yinji Xu⁹  Xiaoling Yuan^1,10  Yiju Zhao^1,11  Meihua Chen^1,12  Yong Jiang^1,13 

[1] State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University;Chronic Airway Disease Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University;Huizhou Third People’s Hospital, Guangzhou Medical University;The First People’s Hospital of Foshan;Shenzhen Second People’s Hospital;The Second People’s Hospital of Zhaoqing;The Second Affiliated Hospital of Guangzhou Medical University;The Third Affiliated Hospital of Sun Yat-sen University;The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine;Zhongshan Hospital of Sun Yat-sen University, Zhongshan People’s Hospital;The Fifth People’s Hospital of Dongguan;The Third People’s Hospital of Dongguan;Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine

关键词: Chronic cough;    quality of life;    burden;    survey;    management;   

DOI  :  10.21037/jtd-21-1737

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: Chronic cough is a troublesome clinical problem with long-term impacts at the patient level. However, the burden of chronic cough in China is largely unknown. Thus, we performed a multicenter cross-sectional survey on the current status of chronic cough and its impact on quality of life in Guangdong, south China. Methods: Using a standardized questionnaire, we extracted and analyzed the relevant data on demographics, number of visits to a doctor, previous diagnosis, previous medications used and initial diagnosis. Cough-specific quality of life was measured by the Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC). Results: Of 933 patients from 13 tertiary medical centers in Guangdong, 52.2% were female, the median age was 40.0 [interquartile range (IQR), 31.0–52.0] years, and the median duration of chronic cough was 6.0 (IQR, 3.0–24.0) months. Over half (n=452, 54.0%) of the patients had visited physicians ≥3 times for cough. In terms of previous diagnosis, bronchitis (n=432, 46.5%) had been most frequently diagnosed, followed by pharyngitis (n=246, 26.5%) and asthmatic cough (n=98, 10.5%). A majority of patients with chronic cough had used antitussive agents (n=539, 58.5%), antibiotics (n=374, 40.6%) and traditional Chinese medicine (TCM) (n=294, 31.9%). Among the three subscales of the LCQ-MC, we observed lower scores in the mental health domain than in the physical and social domains (both P3 times for both the total and three subscale scores (all P<0.05). Conclusions: Misdiagnosis and inappropriate treatment are prevalent in patients with chronic cough and lead to considerable antibiotic abuse. Chronic cough markedly affects suffers’ quality of life, especially for women.

【 授权许可】

Unknown