Feasibility of a prototype carbon nanotube enabled stationary digital chest tomosynthesis system for identification of pulmonary nodules by pulmonologists

Journal of Thoracic Disease

article

Allen Cole Burks¹  Jason Akulian¹  Christina R. MacRosty¹  Sohini Ghosh²  Adam Belanger³  Muthu Sakthivel⁴  Thad S. Benefield⁴  Christina R. Inscoe⁵  Otto Zhou⁵  Jianping Lu⁵  Yueh Z. Lee⁴ 

[1] Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill;Division of Pulmonary and Critical Care, Allegheny Health Network;FirstHealth, Pinehurst Medical Clinic;Department of Radiology, University of North Carolina at Chapel Hill;Department of Physics and Astronomy, University of North Carolina at Chapel Hill

关键词: Tomosynthesis;    pulmonary nodules;    lung cancer;    chest imaging;    bronchoscopy;   

DOI  :  10.21037/jtd-21-1381

学科分类：呼吸医学

来源: Pioneer Bioscience Publishing Company

【 摘 要 】

Background: 8 mm. Bronchoscopic biopsy poses the lowest risk but is paired with the lowest diagnostic yield when compared to CT-guided biopsy or surgery. A need exists for a safe, mobile, low radiation dose, intra-procedural method to localize biopsy instruments within target nodules. This retrospective cross sectional reader feasibility study evaluates the ability of clinicians to identify pulmonary nodules using a prototype carbon nanotube radiation enabled stationary digital chest tomosynthesis system. Methods: Patients with pulmonary nodules on prior CT imaging were recruited and consented for imaging with stationary digital chest tomosynthesis. Five pulmonologists of varying training levels participated as readers. Following review of patient CT and a thoracic radiologist’s interpretation of nodule size and location the readers were tasked with interpreting the corresponding tomosynthesis scan to identify the same nodule found on CT. Results: Fifty-five patients were scanned with stationary digital chest tomosynthesis. The median nodule size was 6 mm (IQR =4–13 mm). Twenty nodules (37%) were greater than 8 mm. The radiation entrance dose for s-DCT was 0.6 mGy. A significant difference in identification of nodules using s-DCT was seen for nodules <8 vs. ≥8 mm in size (57.7% vs. 90.9%, CI: −0.375, −0.024; P<0.001). Inter-reader agreement was fair, and better for nodules ≥8 mm [0.278 (SE =0.043)]. Conclusions: With system and carbon nanotube array optimization, we hypothesize the detection rate for nodules will improve. Additional study is needed to evaluate its use in target and tool co-localization and target biopsy.

【 授权许可】

Unknown