Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population

Cancer Medicine

Jing Lu¹  Yuqing Ding¹  Hongbing Shen¹  Hongxia Ma¹  Wei Zhao¹  Ci Song¹  Ting Tian¹  Hai Xu²  Wenfang Zhu³  Pei Qin³  Qun Zhang³  Wen Guo³  Zhongming Wang⁴ 

[1] Department of Epidemiology, Center for Global Health, School of Public Health Nanjing Medical University Nanjing China;Department of Radiology, Jiangsu Province Hospital and the First Affiliated Hospital of Nanjing Medical University Nanjing China;Health Promotion Center, Jiangsu Province Hospital and the First Affiliated Hospital of Nanjing Medical University Nanjing China;Information Department, Jiangsu Province Hospital and the First Affiliated Hospital of Nanjing Medical University Nanjing China;

关键词: CT scan;    lung cancer;    neutrophil‐to‐lymphocyte ratio;    platelet‐to‐lymphocyte ratio;    pulmonary nodules;    systemic immune‐inflammation index;   

DOI  :  10.1002/cam4.4606

来源: DOAJ

【 摘 要 】

Abstract Objectives Neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and systemic immune‐inflammation index (SII), easily accessible systemic inflammation response parameters, were reported to associate with poor lung cancer prognosis. However, research on the effects of these markers on the risk of positive nodules (PNs) and lung cancer is limited. Methods Participants in this retrospective study were those who had their first computed tomography (CT) screening at Jiangsu Province Hospital's Health Promotion Center between January 1, 2017 and December 31, 2020. We identified PNs (≥6 mm in diameter) from free text of CT reports and lung cancer from medical records. Multivariate logistic analysis was used to assess the association between NLR, PLR, or SII and PNs or lung cancer. Results The detected rate of PNs was 9.60% among the 96,476 participants. Age, smoking and body mass index were possible influencing factors for PNs. We observed linear dose‐effect relationship between NLR, PLR, or SII and PNs (pnon‐linear > 0.05). Compared with low quintile, participants with top quintiles of NLR, PLR or SII had an increased risk of PNs, with the adjusted ORs of 1.19 (1.11–1.28), 1.11 (1.04–1.19) or 1.11 (1.03–1.18), respectively. Meanwhile, NLR showed the U‐shaped relationship with lung cancer, with adjusted ORs of 1.40 (1.08–1.81) comparing highest NLR quintile to the third quintile. The high PLR and SII showed significantly associated with lung cancer with adjusted ORs of 1.29 (0.99–1.68) and 1.35 (1.04–1.74) comparing to the lowest quintile. Conclusions The high levels of systemic inflammation markers were associated with the risk of positive pulmonary nodules and lung cancer, which suggested systemic immune response may be an important pre‐clinical feature for the early identification of diseases.

【 授权许可】

Unknown