Quercetin up-regulates the expression of tumor-suppressive microRNAs in human cervical cancer

Bioscience of Microbiota, Food and Health

article

Motoki MURATA¹  Satomi KOMATSU¹  Emi MIYAMOTO¹  Chihiro OKA¹  Ichian LIN¹  Motofumi KUMAZOE¹  Shuya YAMASHITA¹  Yoshinori FUJIMURA¹  Hirofumi TACHIBANA¹ 

[1] Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University;Advanced Research Support Center, ADRES, Ehime University

关键词: quercetin;    cervical cancer;    microRNA;    β-catenin;   

DOI  :  10.12938/bmfh.2022-056

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

Quercetin, a flavonol present in many vegetables and fruits, has been identified as a chemoprevention agent in several cancer models. However, the molecular mechanism of quercetin’s anticancer activity is not entirely understood. MicroRNAs (miRNAs), small noncoding RNAs, have been reported to play key roles in various biological processes by regulating their target genes. We hypothesized that quercetin can exert an anticancer effect through the regulation of miRNAs. To test this hypothesis, we investigated the effects of quercetin on the expression of tumor-suppressive miRNAs in cervical cancer. Quercetin up-regulated the in vivo and in vitro expression of tumor-suppressive miRNAs miR-26b, miR-126, and miR-320a. Quercetin suppressed the level of β-catenin, encoded by catenin beta 1 (CTNNB1), by up-regulating miR-320a in HeLa cells. Moreover, quercetin increased the expression of mir-26b, mir-126, and mir-320a precursors in HeLa cells. The results from this study show that quercetin has the potential to prevent cervical cancer by regulating the expression of tumor-suppressive miRNAs.

【 授权许可】

CC BY