Clostridium butyricum affects nutrition and immunology by modulating gut microbiota

Bioscience of Microbiota, Food and Health

article

Masateru YAMAMOTO¹  Hiromitsu OHMORI³  Daisuke TAKEI¹  Tomio MATSUMOTO¹  Masahiko TAKEMOTO¹  Masanobu IKEDA¹  Ryo SUMIMOTO¹  Tsuyoshi KOBAYASHI²  Hideki OHDAN² 

[1] Department of Surgery, National Hospital Organization Yanai Medical Center;Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University;Department of Pediatrics, National Hospital Organization Yanai Medical Center

关键词: Clostridium butyricum;    end stage renal disease;    gut microbiota;    hemodialysis;    16S rDNA;   

DOI  :  10.12938/bmfh.2021-046

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

The gut microbiota has nutritional and protective functions. In patients with end-stage renal disease, changes in the gut microbiota disrupt their protective functions. Probiotics help maintain normal bowel function. However, their role in patients with end-stage renal disease is controversial. We investigated whether Clostridium butyricum affects the nutrition and immune function of patients with end-stage renal disease undergoing maintenance dialysis between 2014 and 2015; thirty-seven patients were included. The patients were divided into two groups: one in which C. butyricum was administered and one in which it was not. One tablet of the probiotics, which contained 20 mg of C. butyricum, was administered orally three times daily for 2 years in the C. butyricum group. The 16S rRNA genes were sequenced from stool samples of 14 (37.8%) patients in the C. butyricum group and 23 (62.2%) patients in the control group. The differences in the gut microbiota of the two groups were analyzed. The α-diversity index indicated that the C. butyricum group had significantly more operational taxonomic units and higher albumin and transferrin levels than the control group. The effector to target cell ratio was significantly higher in the C. butyricum group. In addition, interleukin-6 levels were significantly lower in the C. butyricum group, and inflammation was less severe in this group. The patients undergoing maintenance dialysis with C. butyricum had abundant gut microbiota. They also had a good nutritional status, low systemic inflammation, and a good immunological status.

【 授权许可】

CC BY