Mycobacterium leprae and Mycobacterium lepromatosis Infection: a Report of Six Multibacillary Cases of Leprosy in the Dominican Republic

Japanese journal of infectious diseases

article

Juan Daniel Periche Fernández¹  Víctor Enrique Pou-Soarez¹  Roberto Arenas²  Eder Rodrigo Juárez-Duran²  Sofía Lucila Luna-Rojas³  Juan Xicohtencatl-Cortes⁴  Luary Carolina Martínez-Chavarría⁵  Fernando Martínez-Hernández³  Rigoberto Hernández-Castro³ 

[1] Dominican Dermatological Institute and Skin Surgery Dr. Huberto Bogaert;Mycology Service, General Hospital Dr. Manuel Gea González;Department of Ecology of Pathogens, General Hospital Dr. Manuel Gea González;Intestinal Bacteriology Laboratory, Children"s Hospital of Mexico Dr. Federico Gomez;Department of Pathology, Faculty of Veterinary Medicine, National Autonomous University of Mexico

关键词: Mycobacterium leprae;    Mycobacterium lepromatosis;    leprosy;    Dominican Republic;    lepromatous leprosy;   

DOI  :  10.7883/yoken.JJID.2021.709

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

The causative agents of leprosy are Mycobacterium leprae and M. lepromatosis. Mycobacterium lepromatosis was found in 2008 to cause diffuse lepromatous leprosy in Mexican patients. This study aimed to identify M. leprae and M. lepromatosis in paraffin-embedded skin samples from Caribbean patients with leprosy. A total of six skin samples were obtained from the Dominican Republic. All cases presented the multibacillary form; five were nodular lepromatous leprosy, and one was borderline lepromatous leprosy. All patients received multidrug therapy. Molecular identification was achieved using the M. leprae-specific repetitive element for M. leprae and the hemN gene for M. lepromatosis. Mycobacterium leprae was identified in two lepromatous leprosy cases, and one borderline lepromatous leprosy case; M. lepromatosis was found in one nodular lepromatous leprosy case. Both Mycobacterium species were present in two nodular lepromatous leprosy cases. This is the first report of M. lepromatosis in the Dominican Republic.

【 授权许可】

Unknown