Favipiravir and Its Structural Analogs: Antiviral Activity and Synthesis Methods

Acta Naturae

article

Irina D. Konstantinova¹  Valeria L. Andronova²  Ilya V. Fateev¹  Roman S. Esipov¹ 

[1] Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences;Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, FSBI «National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya» of the Ministry of Health of Russia

关键词: 6-fluoro-3-oxopyrazine-2-carboxamide;    favipiravir;    pyrazine-2-carboxamide;    influenza;    SARS-CoV-2.;   

DOI  :  10.32607/actanaturae.11652

学科分类：生物技术

来源: Moskovskii Gosudarstvennyi Universitet im.M.V.Lomonosova/M.V.Lomonosov Moscow State University

【 摘 要 】

1,4-Pyrazine-3-carboxamide-based antiviral compounds have been under intensive study for the last 20 years. One of these compounds, favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide, T-705), is approved for use against the influenza infection in a number of countries. Now, favipiravir is being actively used against COVID-19. This review describes the in vivo metabolism of favipiravir, the mechanism of its antiviral activity, clinical findings, toxic properties, and the chemical synthesis routes for its production. We provide data on the synthesis and antiviral activity of structural analogs of favipiravir, including nucleosides and nucleotides based on them.

【 授权许可】

Unknown