Characterization of Susceptibility Variants of Influenza Virus Grown in the Presence of T-705

Journal of Pharmacological Sciences

Yoshihiro Yoshida¹  Tomoko Okuda¹  Kimiyasu Shiraki¹  Tohru Daikoku¹ 

[1] Department of Virology, University of Toyama, Japan

关键词: influenza virus;    T-705;    favipiravir;   

DOI  :  10.1254/jphs.14156SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)T-705 (favipiravir) is a potent inhibitor of RNA polymerases of influenza viruses. Susceptibility variants were isolated during passages in the presence of T-705. Nine variants with 0.4 to 2.1 times the 50% inhibitory concentration for plaque formation of the parent A/PR/8/34 (H1N1) strain had amino acid variations in the PB1, PB2, and PA genes of the RNA polymerase complex. However, the variation patterns in the RNA polymerase complex indicated that T-705 does not work as a mutagen, and resistant mutants were not isolated, possibly because a mutation leading to resistance would be lethal to the RNA polymerase function.

【 授权许可】

Unknown