Steen solution protects pulmonary microvascular endothelial cells and preserves endothelial barrier after lipopolysaccharide-induced injury

The Journal of Thoracic and Cardiovascular Surgery

article

Huy Q. Ta¹  Nicholas R. Teman¹  Irving L. Kron¹  Mark E. Roeser¹  Victor E. Laubach¹ 

[1] Department of Surgery, University of Virginia School of Medicine

关键词: Steen solution;    in vivo lung perfusion;    acute respiratory distress syndrome;    endothelial barrier dysfunction;   

DOI  :  10.1016/j.jtcvs.2022.04.005

学科分类：心脏病和心血管学

来源: Mosby, Inc.

【 摘 要 】

Acute respiratory distress syndrome represents the devastating result of acute lung injury, with high mortality. Limited methods are available for rehabilitation of lungs affected by acute respiratory distress syndrome. Our laboratory has demonstrated rehabilitation of sepsis-injured lungs via normothermic ex vivo and in vivo perfusion with Steen solution (Steen). However, mechanisms responsible for the protective effects of Steen remain unclear. This study tests the hypothesis that Steen directly attenuates pulmonary endothelial barrier dysfunction and inflammation induced by lipopolysaccharide.

【 授权许可】

Unknown