The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review

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Matthew T.J. Halma¹  Jessica Rose²  Theresa Lawrie¹ 

[1] EBMC Squared CIC;Independent Researcher

关键词: COVID-19 vaccination;    mRNA vaccines;    clinical trials;    safety assessment;    novel technologies;    spike protein;   

DOI  :  10.3390/j6020017

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Pharmacovigilance databases are showing evidence of injury in the context of the modified COVID-19 mRNA products. According to recent publications, adverse event reports linked to the mRNA COVID-19 injections largely point to the spike protein as an aetiological agent of adverse events, but we propose that the platform itself may be culpable. To assess the safety of current and future mRNA vaccines, further analysis is needed on the risks due to the platform itself, and not specifically the expressed antigen. If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe. If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the antigen to be expressed, the platform may be inherently unsafe, pending modification. In this work, we examine previous studies of RNA-based delivery by a lipid nanoparticle (LNP) and break down the possible aetiological elements of harm.

【 授权许可】

CC BY