Recent Advances on Immune Targeted Therapy of Colorectal Cancer Using bi-Specific Antibodies and Therapeutic Vaccines

Biological Procedures Online

Alireza Golchini¹  Shirin Eyvazi²  Fatemeh Abarghooi Kahaki³  Ali Azadi⁴  Sina Delazar⁵  Seyed Mohsen Dehnavi⁶  Zahra Payandeh⁷ 

[1] Cancer surgery Department; Shiraz Medical School, Shiraz University of medical Sciences, Shiraz, Iran;Department of Biology, Tabriz Branch, Islamic Azad University, Tabriz, Iran;Biotechnology Research Center, Tabriz Branch, Islamic Azad University, Tabriz, Iran;Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Medicine, De La Salle Health Sciences Institute, Dasmariñas, Philippines;Department of Radiology, Tehran University of Medical Sciences, Tehran, Iran;Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran;Immunology Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Colorectal cancer;    Cancer vaccines;    Bi-specific antibody;    mRNA vaccines;    Nanobodies;    MGD007;   

DOI  :  10.1186/s12575-021-00147-7

来源: Springer

【 摘 要 】

Colorectal cancer (CRC) is a universal heterogeneous disease that is characterized by genetic and epigenetic alterations. Immunotherapy using monoclonal antibodies (mAb) and cancer vaccines are substitute strategies for CRC treatment. When cancer immunotherapy is combined with chemotherapy, surgery, and radiotherapy, the CRC treatment would become excessively efficient. One of the compelling immunotherapy approaches to increase the efficiency of CRC therapy is the deployment of therapeutic mAbs, nanobodies, bi-specific antibodies and cancer vaccines, which improve clinical outcomes in patients. Also, among the possible therapeutic approaches for CRC patients, gene vaccines in combination with antibodies are recently introduced as a new perspective. Here, we aimed to present the current progress in CRC immunotherapy, especially using Bi-specific antibodies and dendritic cells mRNA vaccines. For this aim, all data were extracted from Google Scholar, PubMed, Scopus, and Elsevier, using keywords cancer vaccines; CRC immunotherapy and CRC mRNA vaccines. About 97 articles were selected and investigated completely based on the latest developments and novelties on bi-specific antibodies, mRNA vaccines, nanobodies, and MGD007.

【 授权许可】

CC BY