Hepatitis B Prevalence among Men Who Have Sex with Men in Brazil

Tropical Medicine and Infectious Disease

article

Ana Rita C. Motta-Castro¹  Lígia Kerr³  Carl Kendall³  Rosa S. Mota⁵  Mark Drew C. Guimarães⁶  Andréa Fachel Leal⁷  Edgar Merchan-Hamann⁸  Inês Dourado⁹  Maria Amélia Veras^1,10  Ana Maria de Brito^1,11  Alexandre Kerr Pontes^1,12  Raimunda Hermelinda M. Macena^1,13  Daniela Knauth^1,14  Luana N. G. C. Lima^1,15  Socorro Cavalcante^1,16  Ximena P. Díaz-Bermúdez^1,17  Lisangela C. Oliveira^1,18  Laio Magno^1,19  Ana Cláudia Camillo^2,20  Marcílio F. Lemos^2,21  Vanessa Cristina M. Silva^2,21  Adriana P. Compri^2,21  Regina Célia Moreira^2,21 

[1] Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul;Fundação Oswaldo Cruz—Mato Grosso do Sul;Saúde Comunitária, Faculdade de Medicina, Universidade Federal do Ceará;Global Community Health and Behavioral Sciences, Tulane University;Departamento de Estatística e Matemática Aplicada, Universidade Federal do Ceará;Medicina Preventiva e Social, Universidade Federal de Minas Gerais;Departamento de Sociologia, Universidade Federal do Rio Grande do Sul;Faculdade de Ciências da Saúde, Saúde Coletiva, Universidade de Brasília;Instituto de Saúde Coletiva, Universidade Federal da Bahia;Departamento de Saúde Coletiva;Departamento de Saúde Coletiva, Fiocruz: Instituto de Pesquisas Aggeu Magalhães, Universidade Federal de Pernambuco;Instituto de Psicologia da Universidade Federal do Rio de Janeiro;Faculdade de Medicina, Universidade Federal do Ceará;Departamento de Medicina Social, Universidade Federal do Rio Grande do Sul;Instituto Evandro Chagas;Secretaria de Saúde do Estado do Ceará;Centro de Ciências da Saúde, Universidade de Brasília;Escola de Saúde, Centro Universitário Autônomo do Brasil UNIBRASIL;Departamento de Ciências da Vida, Universidade do Estado da Bahia;Fundação Alfredo da Mata;Laboratório de Hepatites, Centro de Virologia, Instituto Adolfo Lutz

关键词: MSM;    hepatitis B virus;    respondent-driven sampling;   

DOI  :  10.3390/tropicalmed8040218

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Hepatitis B virus (HBV) is a global public health problem and requires specific prevention actions, particularly focusing on the key populations, such as men who have sex with men (MSM). We aimed at assessing the prevalence of HBV infection, among MSM, in a multicity study in Brazil. In 2016, we conducted a survey using a respondent-driven sampling methodology in 12 Brazilian cities. Rapid tests (RT) were performed on 3178 samples from those MSM. Positive results were tested for HBV DNA and sequenced. If negative for HBV DNA, samples were tested for serological markers. The prevalence rate of HBV exposure and clearance was 10.1% (95% CI: 8.1–12.6), and 1.1% (95%; CI: 0.6–2.1) were confirmed to be HBsAg-positive. Of those samples tested for anti-HBs (n = 1033), only 74.4% presented a serological profile analogous to that elicited by hepatitis B vaccination. Among HBsAg-positive samples (n = 29), 72.4% were HBV DNA-positive, and from these, 18 were sequenced. HBV genotypes A, F, and G were found in 55.5%, 38.9%, and 5.6%, respectively. This study indicates high prevalence rates of MSM HBV exposure and a low positivity index for the serological marker of HBV vaccine immunity. These findings may contribute to the discussion of strategies to prevent hepatitis B and reinforce the importance of promoting HBV vaccination in this key population.

【 授权许可】

CC BY