Synthesis, characterization, anti-microbial and anti-fungal activity studies of four novel 2-aminopyridine and 2,4-dichloro-5-sulfamoylbenzoic acid salts and their Cu(II) complexes

Kuwait Journal of Science

article

halil ilkimen¹  Aysel Gülbandılar² 

[1] Dept. of Chemistry, Faculty of Arts and Sciences, Kütahya Dumlupinar University;Dept. of Food Engineering, Dept. of Agricultural Engineering, Eskişehir Osmangazi University

关键词: 2-Aminopyridine;    anti-microbial and anti-fungal activities;    Cu(II) complexes;    2,4-dichloro-5-sulfamoylbenzoic acid;    proton transfer salt.;   

DOI  :  10.48129/kjs.19163

学科分类：社会科学、人文和艺术（综合）

来源: Kuwait University * Academic Publication Council

【 摘 要 】

Four novel proton transfer compounds (1-4) obtained between 2-aminopyridine (1), 2-amino-4-methylpyridine (2), 2-amino-5-methylpyridine (3), 2-amino-6-methylpyridine (4) and 2,4-dichloro-5-sulfamoylbenzoic acid (Hsba) and their Cu(II) complexes (6-10) have been synthesized. The structures of powdery salts (1-4) and complexes (6-10) have been suggested by spectral (1H-NMR, FT-IR and UV–Vis), elemental analysis, AAS, molar conductivity and magnetic susceptibility techniques of 6-10 have also been reported. The structures of metal complexes (6-10) were observed octahedral according to spectroscopic analysis results. Additionally, anti-microbial and anti-fungal activities of all compounds have been tested against Escherichia coli (ATCC 25922) (Gram negative), Enterococcus faecalis (ATCC 29212) (Gram positive), Staphylococcus aureus (ATCC 29213) (Gram positive), and Candida Albicans (ATCC 14053) (yeast), Candida parapisilosis (ATCC 22019) (yeast), and Candida krusei (ATCC 6258) (yeast). The results were comparisoned with the antibiotics, Fluconazole as anti-fungal agent and Cefepime, Levofloxacin, Vancomycin as anti-microbial agents. Activity against all compounds bacteria and yeasts was observed. Therefore, all compounds may be utilized for the synthesis of new anti-microbial and anti-fungal. Compounds with the best activity are 2 (15.60 μg/mL) for S. aureus, 2, 8 and 11 (31.25 μg/mL) for E. Faecalis, 2a5mp, 1, 2 and 9 (31.25 μg/mL) for E. Coli, Cu(OAc)2.2H2O, 1, 2 and 9 (31.25 μg/mL) for C. Parapsilosis, Hsba (15.60 μg/mL) for C. Albicans and Hsba and 8 (31.25 μg/mL) for C. Krusei.

【 授权许可】

Unknown