Interaction of DNA with Simple and Mixed Ligand Copper(II) Complexes of 1,10-Phenanthrolines as Studied by DNA-Fiber EPR Spectroscopy

International Journal of Molecular Sciences

Makoto Chikira²  Chew Hee Ng¹  Mallayan Palaniandavar³ 

[1] Department of Pharmaceutical Chemistry, International Medical University, Kuala Lumpur 57000, Malaysia; E-Mail:;Department of Applied Chemistry, Chuo University, Kasuga, Bunkyou-ku, Tokyo 112-8551, Japan;Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, India; E-Mail:

关键词: electron paramagnetic resonance;    DNA fiber;    Cu(II) complexes;    1;    10-phenanthrolines;    DNA binding structures;    DNA conformation;   

DOI  :  10.3390/ijms160922754

来源: mdpi

【 摘 要 】

The interaction of simple and ternary Cu(II) complexes of 1,10-phenanthrolines with DNA has been studied extensively because of their various interesting and important functions such as DNA cleavage activity, cytotoxicity towards cancer cells, and DNA based asymmetric catalysis. Such functions are closely related to the DNA binding modes of the complexes such as intercalation, groove binding, and electrostatic surface binding. A variety of spectroscopic methods have been used to study the DNA binding mode of the Cu(II) complexes. Of all these methods, DNA-fiber electron paramagnetic resonance (EPR) spectroscopy affords unique information on the DNA binding structures of the complexes. In this review we summarize the results of our DNA-fiber EPR studies on the DNA binding structure of the complexes and discuss them together with the data accumulated by using other measurements.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.