Plasma D-Dimer as a Marker of Urinary Tract Infection in Children

Nephro-Urology Monthly

article

Maryam Esteghamati¹  Kambiz Ghasemi¹  Zohreh Javaheri²  Ghazal Zoghi³ 

[1] Department of Pediatric Nephrology, Clinical Research Development Center of Children’s Hospital, Hormozgan University of Medical Sciences;Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences;Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences

关键词: Urinary Tract Infections;    Children;    D-Dimer;   

DOI  :  10.5812/numonthly.117054

学科分类：基础医学

来源: Kowsar Corporation

【 摘 要 】

Background: Urinary tract infections (UTIs) are very common in children. Several biomarkers have been used for the diagnosis of UTI and prediction of renal parenchymal involvement. Objectives: This study aimed to evaluate plasma D-dimer as a diagnostic marker of UTI in children. Methods: This cross-sectional study included 41 children aged 1 month to 14 years with their first febrile UTI confirmed by positive urine culture referred to Bandar Abbas Children’s Hospital, Iran, from October 1, 2017, to April 1, 2018. Participants’ demographic features, including age and gender were recorded. White blood cell (WBC) count, percentage of neutrophils, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum D-dimer were measured in random blood samples for all the patients. Results: Out of 41 children (mean age: 5.50 ± 4.01 years) evaluated in this study, 6 (14.6%) were male, and 35 (85.4%) were female. The mean plasma D-dimer level was 1496.49 ± 2787.55 µg/L. A significant positive correlation was found between D-dimer with ESR (r = 0.647, P = 0.026) and CRP (r = 0.525, P = 0.001). Plasma D-dimer was not associated with age; however, age was inversely correlated with WBC count (r = -0.327, P = 0.037). No significant relationship was found between plasma D-dimer, ESR, CRP, WBC count, and neutrophil percentage with gender (P > 0.05). Conclusions: According to our results, in children aged 1 month to 14 years with culture-confirmed UTI, plasma D-dimer is positively correlated with ESR and CRP. Nevertheless, D-dimer appears not to be influenced by age or gender. Further studies are required to confirm the utility of D-dimer as a diagnostic marker of UTI in children.

【 授权许可】

Unknown