D-Dimer plasma levels in patients with coronary artery disease

Revista Brasileira de Hematologia e Hemoterapia

Luciana M. Lima²  Marinez O. Sousa²  Ana Paula Fernandes²  Adriano P. Sabino²  Cirilo P. Fonseca Neto¹  José Carlos F. Garcia¹  Jamil A. Saad¹  Maria Das Graças Carvalho² 

[1] ,Universidade Federal de Minas Gerais Faculdade de Farmácia Belo Horizonte MG ,Brasil

关键词: D-Dimer;    coronary artery disease;    coronary angiography;    Dímero D;    doença arterial coronariana;    angiografia coronariana;   

DOI  :  10.1590/S1516-84842006000400012

来源: SciELO

【 摘 要 】

We have previously reported that prothrombin fragment 1+2 levels were not associated to the presence or severity of coronary artery disease (CAD) and do not provide further information on subjects with CAD diagnosed by angiography. Thus, in the present study another marker of hypercoagulability was evaluated in the same subjects. This study aimed at determining D-Dimer plasma levels in a group of subjects undergoing coronary angiography to establish a likely relation between this parameter and the severity of CAD. D-Dimer plasma levels were determined in 17 subjects with no coronary atheromatosis (controls), 12 subjects with mild/moderate atheromatosis and 28 subjects with severe atheromatosis. No significant differences were observed among the three groups. Data analysis enables an inference on a tendency towards an increase in fibrinolytic activity in patients with atheromatosis, reflected by the increase in D-Dimer concentrations in the severe atheromatosis group in subjects with CAD diagnosed by coronary angiography.

【 授权许可】

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