Effect of N-Acetylcysteine on hsCRP in Patients on Continues Ambulatory Peritoneal Dialysis: A Quasi-Experimental Study

Nephro-Urology Monthly

article

Farzaneh Najafi¹  Razieh Sadat Mousavi-Roknabadi²  Azar Pirdehghan⁴  Masoud Rahimian⁶  Nader Nourimajalan⁶ 

[1] Department of Internal Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences;Emergency Medicine Department, School of Medicine, Shiraz University of Medical Sciences;Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences;Department of Community Medicine, Research Center for Health Sciences, School of Medicine, Hamadan University of Medical Sciences;Department of Community Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences;Department of Internal Medicine, School of Medicine, Shahid Sadoughi General Hospital, Shahid Sadoughi University of Medical Sciences

关键词: C-reactive Protein;    N-Acetylcysteine;    Peritoneal Dialysis;    End-Stage Renal Disease;   

DOI  :  10.5812/numonthly.113990

学科分类：基础医学

来源: Kowsar Corporation

【 摘 要 】

Background: Inflammatory processes are proved in patients with chronic kidney disease (CKD) as one of the leading causes of mortality and morbidity. N-acetylcysteine (NAC) is known as an antioxidant drug with anti-inflammatory effects. Objectives: This study aimed to evaluate the effects of NAC on hsCRP in CKD patients on peritoneal dialysis. Methods: This quasi-experimental self-controlled study examined adult CKD patients on peritoneal dialysis referred to the peritoneal dialysis clinic. The participants were assigned into two groups (A: CRP of 5 - 15 mg/L and B: CRP < 5 mg/L), and both groups were treated with oral NAC 600mg twice a day for eight weeks. First, the hsCRP was measured before and after the intervention, and then all the collected data were analyzed. Results: Forty patients (n = 24 in the group A and n = 26 in the group B) participated in this study. NAC decreased the hsCRP level in both groups (P = 0.001 in the group A vs. P = 0.002 in group B); however, the decrease was more prominent in the group A (P = 0.013). The hsCRP decrease was more significant in women (P = 0.002) in general and women in the group B (P = 0.02) in particular. The hsCRP variation had a significant relationship with the underlying disease (P = 0.009). There was no significant correlation between the hsCRP variation with age (r = -0.173, P = 0.285) and the duration of dialysis. Conclusions: The administration of NAC (600 mg, twice a day for eight weeks) significantly decreased the level of hsCRP in patients on peritoneal dialysis, especially in those with CRP = 5 - 15 mh/L. The decrease has no relationship with age and duration of dialysis; however, it was more highlighted in women.

【 授权许可】

Unknown