Flavonoids in the Treatment of Glioblastoma Using Niosomal Nanocarrier

Jundishapur Journal of Natural Pharmaceutical Products

article

Mahmoud Gharbavi¹  Ayyub Mojaddami² 

[1] Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences;Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences;Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences

关键词: Flavonoids;    Glioblastoma;    Niosome;    Baicalein;    Phloretin;   

DOI  :  10.5812/jjnpp-135027

学科分类：药理学

来源: Jundishapur Journal of Natural Pharmaceutical Products

【 摘 要 】

Cancer is a disorder in which certain cells in the bodygrow out of control and spread to other parts of the bodyas the disease progresses. According to the National Cancer Institute (NCI), in 2022, there were 1,918,040 new cancer cases and 609,360 cancer deaths in the United States(1). Among the types of cancers, glioblastoma (GBM) multiforme is the most aggressive and destructive brain tumor that cannot be cured despitemodern treatmentmethods, including radiotherapy and chemotherapy. The average life expectancy of these patients is about 14.6 months,and less than 5% of the patients can survive more than fiveyears. A concerted effort is urgently needed to identify andcharacterize more effective therapies to alleviate this devastating loss of human life (2, 3).

【 授权许可】

CC BY-NC