Bovine leukemia virus-associated B cell lymphoma with severe pleomorphism in a steer

The Journal of Veterinary Medical Science

article

Akiyo HAGIWARA¹  Asami NISHIMORI²  Shinichi HATAMA²  Osamu MIKAMI³  Yoshiharu ISHIKAWA³  Koichi KADOTA³ 

[1] Saitama Prefecture Meat Inspection Center;National Institute of Animal Health, National Agriculture and Food Research Organization;Sapporo Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization

关键词: bovine leukemia virus;    cattle;    inverse polymerase chain reaction;    multiclonality;    pleomorphic lymphoma;   

DOI  :  10.1292/jvms.21-0607

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

200,000 copies per 100,000 cells by quantitative RT-PCR was considered to be due to random integration of the provirus into the neoplastic cells´ genomes. Inverse PCR identified the presence of one, two, two and three different malignant clones in the heart, spleen, mesenteric node and blood, respectively. Because BLV can rapidly induce lymphoma and a high proviral load facilitates B-cell carcinogenesis, multiclonal tumor development was suspected in the present case.

【 授权许可】

Unknown