Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass

The Journal of Veterinary Medical Science

article

Sho YOSHIMOTO¹  Shingo MAEDA²  Takayuki NAKAGAWA¹  Ryohei NISHIMURA¹  Takahisa MURATA³  Taiki KIDA³  Arisa YAMAZAKI³  Tatsuro NAKAMURA³  Koji KOBAYASHI³ 

[1] Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: dog;    liver mass;    lipid metabolite;    urine;   

DOI  :  10.1292/jvms.22-0191

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Fatty acids are an essential component of mammalian bodies. They go through different metabolic pathways depending on physiological states and inflammatory stimuli. In this study, we conducted a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based comprehensive analysis of lipid metabolites in urine of canine patients with liver mass. There were significant differences in quantity of some lipid metabolites that may be closely associated with the disease and/or general inflammatory responses, including increased metabolites of prostaglandin E2 and/or PGF2α. We demonstrated that our approach of profiling lipid metabolites in the urine is useful in gaining insights into the disease. These findings may also have an application as a screening test or a diagnosis tool for canine liver mass.

【 授权许可】

Unknown