Investigation of the Analgesic Properties L-759,633 and SER 601 in Experimental Neuropathic Pain Model in Rats and their Comparison with Pregabalin

Cumhuriyet Science Journal

article

Zıad JOHA¹  Şahin YILDIRIM²  Levent HACISÜLEYMAN²  Ahmet Şevki TAŞKIRAN² 

[1] cumhuriyet university;SİVAS CUMHURİYET ÜNİVERSİTESİ

关键词: Neuropathic pain;    L-759;    633;    SER 601;    Hot plate;    Pregabalin.;   

DOI  :  10.17776/csj.1060972

学科分类：工程和技术（综合）

来源: Cumhuriyet University

【 摘 要 】

Despite the fact that narcotics and NSAIDs are the mainstays of nociceptive pain care, only a small proportion of neuropathic pain patients benefit from them. Cannabinoid agents could be a viable alternative to opioids in the management of chronic pain. The goal of our investigation was to assess the analgesic efficacy of SER 601 and L-759,633, cannabinoid receptor 2 (CB2) agonists, at various doses in a model of neuropathic pain generated in rat. The analgesic effect of CB2 agonists L-759,633 and SER 601 at various doses in a rat model of neuropathic pain created by partial sciatic nerve ligation was examined by the hot plate method. Furthermore, a comparison of analgesic effects of both drugs with pregabalin is also conducted. The two substances demonstrated a dose-dependent analgesic effect in this model. The analgesic response of SER601 and L-759,633 in the neuropathic pain model was higher compared to that of pregabalin. All in all, our data suggest that SER601 and L-759,633 may offer a beneficial treatment option for neuropathic pain in future.

【 授权许可】

CC BY-NC-ND