Original research: Association between personality traits and experience of adverse periocular reactions to topical prostaglandin analogues

BMJ Open Ophthalmology

article

Nanami Kishimoto¹  Takahiko Noro¹  Fumitoshi Kodaka²  Mei Kurosawa¹  Yoshinori Itoh¹  Shumpei Ogawa¹  Tomoyuki Watanabe¹  Masaomi Kubota¹  Kiyotaka Hori³  Masahiro Shigeta²  Tadashi Nakano¹ 

[1] Department of Ophthalmology , The Jikei University School of Medicine;Department of Psychiatry , The Jikei University School of Medicine;Japan Medical Affairs , Santen Pharmaceutical Co Ltd

关键词: glaucoma;    eye lids;    treatment other;   

DOI  :  10.1136/bmjophth-2021-000946

学科分类：工业工程学

来源: BMJ Publishing Group

【 摘 要 】

Background Aesthetically unappealing adverse periocular reactions to prostaglandin (PG) eye-drops are a major challenge in glaucoma treatment. This study analysed the personality traits of patients with glaucoma based on a five-factor model and examined the associations between these factors and adverse periocular reactions.Methods One hundred and forty-seven patients with glaucoma were surveyed anonymously regarding their personality traits and how often adverse periocular reactions were experienced.Results The analysis included 117 valid responses (71 men and 46 women, age: 61.9±11.5 years). Patients who experienced hypertrichosis of the eyelashes scored significantly higher on extraversion (p<0.05), with no significant differences in the other four personality traits. Patients who experienced eyelid hyperpigmentation and deepening of the upper eyelid sulcus showed no significant differences in any of the personality traits. Younger patients scored significantly higher on hypertrichosis (p<0.05).Conclusion The experience of adverse reactions differed according to patient age and personality traits. Therefore, eye-drops should be chosen based on these factors.Trial registration number UMIN000035155.

【 授权许可】

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