Ophthalmic Drug Delivery in Glaucoma—A Review

Pharmaceutics

Ingrida Januleviciene¹  Lina Siaudvytyte² 

[1] id="af1-pharmaceutics-04-00243">Eye Clinic of Lithuanian University of Health Sciences, Kaunas 50009, Lithuan

关键词: glaucoma;    pharmacokinetics;    drug penetration;    topical application;   

DOI  :  10.3390/pharmaceutics4010243

来源: mdpi

【 摘 要 】

Glaucoma is a progressive optic neuropathy and medical therapy is the initial option for the treatment of this potentially blinding condition. Topical instillation of eye drops from the bottle is the most common glaucoma drug delivery form. Due to limited permeability of anterior ocular surface, natural clearance and drainage, eye drops contain large amounts of inactive ingredients. Effective penetration enhancers are known as irritants causing ocular discomfort. Although drug efficacy is determined by active ingredients, inactive agents can affect tolerance and can result in conjunctival irritation and hyperemia and influence patients’ adherence and quality of life.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.