Risk factors for carotid plaque progression after optimising the risk factor treatment: substudy results of the Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the carotid Bifurcation Plaque Study (ANTIQUE)

Stroke and Vascular Neurology

article

David Školoudík¹  Petra Kešnerová³  Tomáš Hrbáč⁵  David Netuka⁷  Jaroslav Vomáčka⁸  Kateřina Langová^1,10  Roman Herzig^1,11  Tomáš Belšan^1,13 

[1] Center for Health Research , Faculty of Medicine, University of Ostrava;Department of Neurology , University Hospital Ostrava;Department of Neurology , Second Faculty of Medicine, Charles University;Department of Neurology , Motol University Hospital;Department of Neurosurgery , Faculty of Medicine, University of Ostrava;Department of Neurosurgery , University Hospital Ostrava;Department of Neurosurgery , Military University Hospital Prague;Department of Radiological Assistance , Faculty of Health Sciences, Palacký University Olomouc;Deaprtment of Radiology , University Hospital Olomouc;Department of Biophysics , Faculty of Medicine, Palacký University Olomouc;Department of Neurology , University Hospital Hradec Králové;Department of Neurology , Faculty of Medicine in Hradec Králové, Charles University;Department of Radiology , Military University Hospital Prague

关键词: ultrasonography;    atherosclerosis;    plaque;    stenosis;   

DOI  :  10.1136/svn-2021-001068

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Background and aim Carotid plaque progression contributes to increasing stroke risk. The study aims to identify factors influencing carotid plaque thickness progression after changing the preventive treatment to the ‘treating arteries instead of risk factors’ strategy, that is, change in treatment depending on the progression of atherosclerosis.Methods2σ, respectively) were included to analysis. Univariate and multivariate logistic regression analysis was performed to identify factors influencing plaque progression.Results A total of 1391 patients (466 males, age 67.2±9.2 years) were enrolled in the study. Progressive plaque in at least one carotid artery was detected in 255 (18.3%) patients. Older age, male sex, greater plaque thickness, coronary heart disease, vascular surgery/stenting history and smoking were more frequently present in patients with progressive plaque (p˂0.05 in all cases). Multivariate logistic regression analysis identified only the plaque thickness (OR 1.850 for left side, 95% CI 1.398 to 2.449; and OR 1.376 for right side, 95% CI 1.070 to 1.770) as an independent factor influencing plaque progression.Conclusion Carotid plaque thickness corresponding to stenosis severity is the only independent risk factor for plaque thickness progression after optimising the prevention treatment.Trial registration numberNCT02360137.

【 授权许可】

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