Haemodynamic analysis of adult patients with moyamoya disease: CT perfusion and DSA gradings

Stroke and Vascular Neurology

article

Zhiyong Shi¹  Guofeng Ma²  Dong Zhang¹ 

[1] Department of Neurosurgery, Beijing Tiantan Hospital , Capital Medical University;Department of Radiology, Beijing Tiantan Hospital , Capital Medical University

关键词: angiography;    blood flow;    CT perfusion;    hemorrhage;    stroke;   

DOI  :  10.1136/svn-2019-000317

学科分类：社会科学、人文和艺术（综合）

来源: BMJ Publishing Group

【 摘 要 】

Object Moyamoya disease (MMD) is a common and chronic progressive stenotic-occlusive cerebrovascular disease in Eastern Asia. To evaluate the hemispheric haemodynamic status of adult patients with MMD, we explored the potential risk factors of hemispheric perfusion alterations with CT perfusion (CTP) and DSA.Methods We retrospectively reviewed 44 male and 44 female (176 hemispheres) adult patients with MMD who had both DSA and CTP. Data on cerebral blood perfusion (CBF), cerebral blood volume (CBV), mean transmit time (MTT), time to peak (TTP) of cerebral hemisphere and cerebellum were gathered and difference of relative haemodynamic parameters between different subgroups were assessed with independent sample t analysis, one-way analysis of variance and general linear regression analysis.Results0.05).Conclusions In adult MMD patients, age, gender and clinical type were potential risk factors for the change of cerebral perfusion. When arterial stenosis is worsened, moyamoya vessels could alter perfusion of temporal and parietal lobe, but not frontal lobe. Extracranial/intracranial compensatory arteries could maintain microcirculation stability in frontal lobe and basal ganglia, indicating that the protection from extracranial compensatory arteries, a theoretic base for surgery treatment if necessary.

【 授权许可】

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