Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?

Applied Sciences

Marcel T. Bernucci¹  Vivek J. Srinivasan¹  Conrad W. Merkle¹  Jun Zhu¹  Shau Poh Chong¹ 

[1] Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA;

关键词: optical coherence tomography;    angiography;    scattering;    red blood cells;    rheology;    imaging;    hemodynamics;    blood flow;   

DOI  :  10.3390/app7070687

来源: DOAJ

【 摘 要 】

Optical Coherence Tomography Angiography (OCTA) refers to a powerful class of OCT scanning protocols and algorithms that selectively enhance the imaging of blood vessel lumens, based mainly on the motion and scattering of red blood cells (RBCs). Though OCTA is widely used in clinical and basic science applications for visualization of perfused blood vessels, OCTA is still primarily a qualitative tool. However, more quantitative hemodynamic information would better delineate disease mechanisms, and potentially improve the sensitivity for detecting early stages of disease. Here, we take a broader view of OCTA in the context of microvascular hemodynamics and light scattering. Paying particular attention to the unique challenges presented by capillaries versus larger supplying and draining vessels, we critically assess opportunities and challenges in making OCTA a quantitative tool.

【 授权许可】

Unknown