Impact of preinterventional arterial remodeling on neointimal hyperplasia after implantation of (non-polymer-encapsulated) paclitaxel-coated stents - A serial volumetric intravascular ultrasound analysis from the ASian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)

Article

关键词: INTIMAL HYPERPLASIA;    COMPENSATORY ENLARGEMENT;    CORONARY-ARTERIES;    INTERVENTIONS;    PREVENTION;    RESTENOSIS;    LESIONS;   

DOI  :  10.1161/01.CIR.0000091254.73351.D6

来源: SCIE

【 摘 要 】

Background-This study used serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of preinterventional arterial remodeling on in-stent intimal hyperplasia (IH) after implantation of non-polymer-encapsulated paclitaxel-coated stents. Methods and Results-Patients were randomized to placebo or one of two doses of paclitaxel ( low dose, 1.28 mug/mm(2); high dose, 3.10 mug/mm(2)). Complete preinterventional, post-stent implantation, and follow-up IVUS were available in 18 low-dose and 21 high-dose patients. IH volumes were similar in low-dose and high-dose patients: 17.6+/-15.1 mm(3) in low-dose patients and 13.1+/-13.3 mm(3) in high-dose patients (P=0.3). Therefore, IVUS findings in low- and high-dose patients were combined. Preinterventional remodeling was assessed by comparing lesion site to proximal and distal reference arterial area: positive remodeling (lesion>proximal reference, n=13), intermediate remodeling ( distal reference

【 授权许可】

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