Molecular magnetic resonance imaging of atrial clots in a swine model | |
Article | |
关键词: CONTRAST AGENT; IN-VIVO; CORONARY-THROMBOSIS; MRI; ECHOCARDIOGRAPHY; CARDIOVERSION; FIBRILLATION; APPENDAGE; MASSES; PLAQUE; | |
DOI : 10.1161/CIRCULATIONAHA.104.529941 | |
来源: SCIE |
【 摘 要 】
Background - The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots. Methods and Results - Chronic human thrombi were surgically implanted in the left atrial appendage of 5 swine. Molecular MRI was performed with a navigator-gated, free-breathing, cardiac-triggered 3D inversion-recovery, black-blood, gradient-echo sequence before and after systemic administration of 4 mu mol/kg EP-2104R. MR images were analyzed by 2 investigators, and the contrast-to-noise ratio was calculated. Location of clots was confirmed by autopsy, and the gadolinium concentration in the clots was assessed. Before contrast agent administration, thrombi were not visible on black-blood MR images. After contrast administration, all atrial clots ( n = 5) were selectively visualized as white spots with a high contrast-to-noise ratio (clot/blood, 29.7 +/- 8.0). The gadolinium concentration in the clots averaged 74 +/- 45 mu mol/L. Conclusions - The fibrin-specific MR contrast agent EP-2104R allows for selective and high-contrast visualization of left atrial clots by means of molecular targeted MRI.
【 授权许可】
Free