Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor ROR alpha

Article

关键词: APOLIPOPROTEIN-A-I;    HIGH-DENSITY-LIPOPROTEIN;    INFLAMMATORY GENE INDUCTION;    GLAND HORMONE MELATONIN;    CORONARY HEART-DISEASE;    APOA-I;    ORPHAN RECEPTORS;    TRANSGENIC MICE;    INBRED STRAINS;    EXPRESSION;   

DOI  :  10.1161/01.CIR.98.24.2738

来源: SCIE

【 摘 要 】

Background-Hypoalphalipoproteinemia is the most common lipoprotein abnormality in patients with coronary artery disease, yet its causes are unknown. Methods aad Results-We show that the homozygous staggerer (sg/sg) mutant mouse, which carries a deletion within the nuclear receptor ROR alpha gene, develops severe atherosclerosis when maintained on an atherogenic diet. In addition, sg/sg mice display a profound hypoalphalipoproteinemia, which is associated with decreased plasma levels of the major HDL proteins, apolipoprotein (apo) A-I and apoA-II. This decrease in HDL levels in sg/sg mice is due to lowered apoA-I gene expression in the intestine but not in the liver. ApoA-II gene expression is unaffected. Conclusions-These results suggest that the ROR alpha gene contributes to the plasma HDL level and susceptibility to atherosclerosis.

【 授权许可】

Free